Nucleora runs entirely on your machine — your sequences never leave your computer. Here's how the pieces fit together.
Nucleora is a Python application that runs a local web server on your machine. When you launch it, it opens in your browser — but everything happens locally.
Nucleora uses established bioinformatics libraries — the same ones you'd use in a Python script or a published paper.
Every calculation traces to a named, published algorithm — not a black box.
Codon optimization is only as good as the codon-usage data. Nucleora ships tables built from NCBI RefSeq coding sequences — not inherited from generic "mammalian" approximations.
The only network requests Nucleora makes are database lookups that you initiate — searching for an antigen, fetching a sequence by accession.
Results are cached locally. Core computation — folding, optimization, primer design — works fully offline.
When Nucleora becomes available, it will use a double-click launcher that handles everything automatically — no terminal commands, no manual configuration.
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